Having sat out Saturday’s 2-1 home loss to Liverpool in the Premier League, all three players will not feature in Milan on Tuesday.
Lloris is expected to be out for “several weeks” with a thigh injury but Alli’s hamstring problem, sustained on international duty with England, is less serious.
Sissoko also has a hamstring injury and will not be available for the San Siro fixture, the first for both teams in Group B.
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